Where 60 represents MW of urea and 14*2 MW of urea nitrogen. If your liver isnt healthy, it may not break down proteins the way it should. Its carried in your blood, filtered out by your kidneys, and removed from your body in your urine. Urea nitrogen is a waste product made when your liver breaks down protein. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L A blood urea nitrogen (BUN) test measures the amount of urea nitrogen found in your blood. United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. Normal ranges vary depending on the reference range used by the lab, but anywhere between 10-20 mg/dL is considered normal. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. A normal eGFR is greater than 90, but values as low as 60 are considered normal if there is no other evidence of kidney disease. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of renal (kidney) health. It is not considered as reliable as creatinine or BUN/creatinine ratio blood studies. The test is used to detect renal problems. If the result is below the normal ratio, then it. It is linked with kidney-related diseases or decreased flow of blood to the kidneys secondary to dehydration or congestive heart failure. If the result is higher than the numbers mentioned, it indicates that there is a high level of BUN in the blood. Individual laboratories will have different reference ranges, as the assay used can vary between laboratories. The ideal ratio is between 10:1 and 20:1. Normal human adult blood should contain 6 to 20 mg/dL (2.1 to 7.1 mmol/L) of urea nitrogen. The liver produces urea in the urea cycle as a waste product of the digestion of protein. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood.
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